To show that something is “possible” or “impossible” does not seem, for Hegel, to be a genuine concern for philosophy. In point of fact, “everything is possible,” because everything has the simple form of identity-with-itself, i.e., does not contradict itself, - and it is equally true that “everything is impossible,” because, in any concrete content, the determinacy can be taken as determined opposition and so as contradiction. Hegel therefore concludes that there is “no emptier talk” than that of such “possibilities” (...) and “impossibilities”. (shrink)

This was the title of a symposium held in Moscow, May 27–30, 1986, and organized by the “International Association for the Study of Dialectical Philosophy—Societas Hegeliana,” in collaboration with the Institute for Philosophy of the Academy of Sciences of the U.S.S.R. Participation was by invitation only. Thirteen participants came from the Federal Republic of Germany, twelve from the U.S.S.R., six from the Democratic Republic of Germany, four each from France and Italy, two from Bulgaria, as well as one each from (...) Czechoslovakia, Hungary, Finland, Austria, Switzerland, Israel, Japan, the Netherlands, and Canada. Papers had been distributed previously and were briefly summarized to allow for more lengthy discussions. The two languages used were Russian and German. Simultaneous translation was provided. (shrink)

Translations, especially of important texts, tend to be controversial. In a collaborative translation, the controversy will start during the process itself, and may persist until the end. In our case this is reflected in two translators’ introductions. Translators and reviewers agree or disagree on the basis of certain principles. There are, one could say, two “schools”: those in favor of more contextual choices of terminology, and those striving for strict consistency. The first will be more inclined to distinguish between “technical” (...) and “non-technical” uses of the same term, and consider this to be part of the translator’s role. The latter will try to avoid making these distinctions, and leave as much room as possible for the reader to decide. The first also tend to see the translation as standing on its own, readily intelligible to those who are without any knowledge of the original language. The latter intend to serve primarily readers who are interested in developing some, progressively better, knowledge of the text in its original language. They will attach more importance to an extensive glossary, which ideally should be applicable to the translated author’s entire corpus. (shrink)

‘et quid agam?’ ‘rogat! en saperdas aduehe Ponto, castoreum, stuppas, hebenum, tus, lubrica Coa. 135 tolle recens primus piper et sitiente camelo. uerte aliquid; iura.’ In 1. 136, Clausen's’ adoption of et from the best manuscripts would warm the heart of A. E. Housman, who takes exception to the e, ex, and ec of other editors : ‘Spell it as you will, the preposition is not natural: the camel carried the pepper on his back, not in any of his numerous (...) stomachs; and it does not follow that we ought to say “tollere piper e camelo” because there exist such phrases as “desilire ex equo”.’ Instead, he takes both primus and sitiente camelo as adverbial adjuncts to the predicate which are parallel in force and therefore united by the conjunction et. (shrink)

‘et quid agam?’ ‘rogat! en saperdas aduehe Ponto, castoreum, stuppas, hebenum, tus, lubrica Coa. 135 tolle recens primus piper et sitiente camelo. uerte aliquid; iura.’In 1. 136, Clausen's’ adoption of et from the best manuscripts would warm the heart of A. E. Housman, who takes exception to the e, ex, and ec of other editors : ‘Spell it as you will, the preposition is not natural: the camel carried the pepper on his back, not in any of his numerous stomachs; (...) and it does not follow that we ought to say “tollere piper e camelo” because there exist such phrases as “desilire ex equo”.’ Instead, he takes both primus and sitiente camelo as adverbial adjuncts to the predicate which are parallel in force and therefore united by the conjunction et. (shrink)

Contemporary Perspectives in Critical and Social Philosophy brings together a range of essays concerning ways of conceptualising modernities, subjectivities, and recognition. It highlights recent developments in German critical and social philosophy and includes essays by Martin Seel, Christoph Menke, Max Pensky, Andrew Bowie, and Karl Ameriks, and critical discussions of the works of Manfred Frank, Theodor Adorno and Axel Honneth.

At fertilization in mammals the sperm activates the egg by triggering a series of oscillations in the intracellular free Ca2+ concentration. The precise sequence of events that occur between sperm‐egg contact and the increases in intracellular Ca2+ remains unknown. Here, we discuss recent evidence supporting the hypothesis that a cytosolic sperm protein enters the egg after gamete membrane fusion and triggers Ca2+ oscillations from within the egg cytoplasm. Biochemical studies suggest that there exists a novel sperm protein, named oscillin, that (...) specifically comigrates with Ca2+ oscillation‐inducing activity. Oscillin has been immunolocalised to the region of the sperm that first fuses with the egg. The concept of a specific protein that triggers Ca2+ oscillations may have wider physiological significance since sperm oscillin can induce Ca2+ oscillations in somatic cells, such as neurons and hepatocytes. Unravelling the novel signalling system involved in mammalian fertilization may help reveal some fundamental molecular mechanisms responsible for triggering cytoplasmic Ca2+ oscillations. (shrink)

We have discovered that a single sperm protein, phospholipase C‐zeta (PLCζ), can stimulate intracellular Ca2+ signalling in the unfertilized oocyte (‘egg’) culminating in the initiation of embryonic development. Upon fertilization by a spermatozoon, the earliest observed signalling event in the dormant egg is a large, transient increase in free Ca2+ concentration. The fertilized egg responds to the intracellular Ca2+ rise by completing meiosis. In mammalian eggs, the Ca2+ signal is delivered as a train of long‐lasting cytoplasmic Ca2+ oscillations that begin (...) soon after gamete fusion and persist beyond the completion of meiosis. Sperm PLCζ effects Ca2+ release from egg intracellular stores by hydrolyzing the membrane lipid PIP2 and consequent stimulation of the inositol 1,4,5‐trisphosphate (InsP3) receptor Ca2+‐signalling pathway, leading to egg activation and early embryogenesis. Recent advances have refined our understanding of how PLCζ induces Ca2+ oscillations in the egg and also suggest its potential dysfunction as a cause of male infertility. (shrink)

The ideal of humanity.--The federation of humanity.--The moral progress of humanity.

Plasminogen activator inhibitor‐1 (PAI‐1) is a physiological inhibitor of urokinase (uPA), a serine protease known to promote cell migration and invasion. Intuitively, increased levels of PAI‐1 should be beneficial in downregulating uPA activity, particularly in cancer. By contrast, in vivo, increased levels of PAI‐1 are associated with a poor prognosis in breast cancer. This phenomenon is termed the “PAI‐1 paradox”. Many factors are responsible for the upregulation of PAI‐1 in the tumor microenvironment. We hypothesize that there is a breast cancer (...) predisposition to a more aggressive stage when PAI‐1 is upregulated as a consequence of Metabolic Syndrome (MetS). MetS exerts a detrimental effect on the breast tumor microenvironment that supports cancer invasion. People with MetS have an increased risk of coronary heart disease, stroke, peripheral vascular disease and hyperinsulinemia. Recently, MetS has also been identified as a risk factor for breast cancer. We hypothesize the existence of the “PAI‐1 cycle”. Sustained by MetS, adipocytokines alter PAI‐1 expression to promote angiogenesis, tumor‐cell migration and procoagulant microparticle formation from endothelial cells, which generates thrombin and further propagates PAI‐1 synthesis. All of these factors culminate in a chemotherapy‐resistant breast tumor microenvironment. The PAI‐1 cycle may partly explain the PAI‐1 paradox. In this hypothesis paper, we will discuss further how MetS upregulates PAI‐1 and how an increased level of PAI‐1 can be linked to a poor prognosis. BioEssays 29:1029–1038, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The development of robots that closely resemble human beings can contribute to cognitive research. An android provides an experimental apparatus that has the potential to be controlled more precisely than any human actor. However, preliminary results indicate that only very humanlike devices can elicit the broad range of responses that people typically direct toward each other. Conversely, to build androids capable of emulating human behavior, it is necessary to investigate social activity in detail and to develop models of the cognitive (...) mechanisms that support this activity. Because of the reciprocal relationship between android development and the exploration of social mechanisms, it is necessary to establish the field of android science. Androids could be a key testing ground for social, cognitive, and neuroscientific theories as well as platform for their eventual unification. Nevertheless, subtle flaws in appearance and movement can be more apparent and eerie in very humanlike robots. This uncanny phenomenon may be symptomatic of entities that elicit our model of human other but do not measure up to it. If so, very humanlike robots may provide the best means of pinpointing what kinds of behavior are perceived as human, since deviations from human norms are more obvious in them than in more mechanical-looking robots. In pursuing this line of inquiry, it is essential to identify the mechanisms involved in evaluations of human likeness. One hypothesis is that, by playing on an innate fear of death, an uncanny robot elicits culturally-supported defense responses for coping with death’s inevitability. An experiment, which borrows from methods used in terror management research, was performed to test this hypothesis. [Thomson Reuters Essential Science Indicators: Fast Breaking Paper in Social Sciences, May 2008]. (shrink)

Japan has more robots than any other country with robots contributing to many areas of society, including manufacturing, healthcare, and entertainment. However, few studies have examined Japanese attitudes toward robots, and none has used implicit measures. This study compares attitudes among the faculty of a US and a Japanese university. Although the Japanese faculty reported many more experiences with robots, implicit measures indicated both faculties had more pleasant associations with humans. In addition, although the US faculty reported people were more (...) threatening than robots, implicit measures indicated both faculties associated weapons more strongly with robots than with humans. Despite the media’s hype about Japan’s robot ‘craze,’ response similarities suggest factors other than attitude better explain robot adoption. These include differences in history and religion, personal and human identity, economic structure, professional specialization, and government policy. Japanese robotics offers a unique reference from which other nations may learn. (shrink)

It can be creepy to notice that something human-looking is not real. But can sensitivity to this phenomenon, known as the uncanny valley, be predicted from superficially unrelated traits? Based on results from at least 489 participants, this study examines the relation between nine theoretically motivated trait indices and uncanny valley sensitivity, operationalized as increased eerie ratings and decreased warmth ratings for androids presented in videos. Animal Reminder Sensitivity, Neuroticism, its Anxiety facet, and Religious Fundamentalism significantly predicted uncanny valley sensitivity. (...) In addition, Concern over Mistakes and Personal Distress significantly predicted android eerie ratings but not warmth. The structural equation model indicated that Religious Fundamentalism operates indirectly, through robot-related attitudes, to heighten uncanny valley sensitivity, while Animal Reminder Sensitivity increases eerie ratings directly. These results suggest that the uncanny valley phenomenon may operate through both sociocultural constructions and biological adaptations for threat avoidance, such as the fear and disgust systems. Trait indices that predict uncanny valley sensitivity warrant investigation by experimental methods to explicate the processes underlying the uncanny valley phenomenon. (shrink)

Karl Morrison discusses historical writing at a turning point in European culture: the so-called Renaissance of the twelfth century. Why do texts considered at that time to be masterpieces seem now to be fragmentary and full of contradictions? Morrison maintains that the answer comes from ideas about art. Viewing histories as artifacts made according to the same aesthetic principles as paintings and theater, he shows that twelfth-century authors and audiences found unity not in what the reason read in a (...) text but in what the imagination read into it: they prized visual over verbal imagination and employed a circular, or nuclear, spectator-centered perspective cast aside in the Renaissance of the fourteenth and fifteenth centuries. Twelfth-century writers assimilated and transformed a tradition of the conceptual unity of all the arts and attributed that unity to the fact that art both conceals and discloses. Recovering that tradition, especially the methods and motives of concealment, provides extraordinary insights into twelfth-century ideas about the kingdom of God, the status of women, and the nature of time itself. It also identifies a strain in European thought that had striking affinities to methods of perception familiar in Oriental religions and that proved to be antithetic to later humanist traditions in the West. Originally published in 1990. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)